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Eur Arch Otorhinolaryngol. 2011 Aug;268(8):1201-1204. doi: 10.1007/s00405-010-1481-y. Epub 2011 Jan 8.

Vitamin D status is associated with disease-free survival and overall survival time in patients with squamous cell carcinoma of the upper aerodigestive tract.

Author information

1
Department of Phoniatrics, ENT University Hospital Graz, Medical University Graz, Auenbruggerplatz 26-28, 8036, Graz, Austria. markus.gugatschka@klinikum-graz.at.
2
Department of Phoniatrics, ENT University Hospital Graz, Medical University Graz, Auenbruggerplatz 26-28, 8036, Graz, Austria.
3
Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University Graz, Graz, Austria.
4
Unit of Biostatistics, Center for Medical Research, Medical University, Graz, Austria.

Abstract

Considerable clinical and experimental data suggest that vitamin D plays a role in pathogenesis and progression of cancer; nevertheless clinical data for head and neck squamous cell carcinoma (HNSCC) are not available. The aim of our study was to associate tumor and clinical characteristics with status of vitamin D [25-hydroxyvitamin D (25(OH)D)]. 88 patients with newly diagnosed squamous cell carcinoma of the head and neck were included in the study. A blood draw was taken at the time of diagnosis. The observation period lasted from 2006 until 2010.

RESULTS:

When compared to a cohort from an epidemiological study, serum levels of 25(OH)D were significantly reduced in patients with HNSCC. We furthermore found disease-free survival, as well as overall survival times to be significantly associated with 25(OH)D levels. In conclusion, results from our study suggest an influence of vitamin D status on cancer incidence, as well as on mortality of HNSCC.

PMID:
21221617
DOI:
10.1007/s00405-010-1481-y
[Indexed for MEDLINE]

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