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Drug Discov Today Technol. 2011;7(1):e5-e11.

Label-Free Receptor Assays.

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1
Biochemical Technologies, Science and Technology Division, Corning Inc., Sullivan Park, Corning, NY 14831, Tele: 607-9747203.

Abstract

Label-free biosensors offer integrated, kinetic and multi-parametric measures of receptor biology and ligand pharmacology in whole cells. Being highly sensitive and pathway-unbiased, label-free receptor assays can be used to probe the systems cell biology including pleiotropic signaling of receptors, and to characterize the functional selectivity and phenotypic pharmacology of ligand molecules. These assays provide a new dimension for elucidating receptor biology and for facilitating drug discovery.

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