Format

Send to

Choose Destination
Organogenesis. 2010 Oct-Dec;6(4):225-33. doi: 10.4161/org.6.4.12555.

Tissue repair: The hidden drama.

Author information

1
Department of Pathology, University of Minnesota School of Medicine, Duluth Campus, Duluth, MN, USA. kkrafts@d.umn.edu

Abstract

As living beings who encounter every kind of traumatic event from paper cut to myocardial infarction, we must possess ways to heal damaged tissues. While some animals are able to regrow complete body parts following injury (such as the earthworm who grows a new head following bisection), humans are sadly incapable of such feats. Our means of recovery following tissue damage consists largely of repair rather than pure regeneration. Thousands of times in our lives, a meticulously scripted but unseen wound healing drama plays, with cells serving as actors, extracellular matrix as the setting, and growth factors as the means of communication. This article briefly reviews the cells involved in tissue repair, their signaling and proliferation mechanisms, and the function of the extracellular matrix, then presents the actors and script for the three acts of the tissue repair drama.

PMID:
21220961
PMCID:
PMC3055648
DOI:
10.4161/org.6.4.12555
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center