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J Clin Oncol. 2011 Feb 10;29(5):591-9. doi: 10.1200/JCO.2010.31.0904. Epub 2011 Jan 10.

Leukemia stem cells and microenvironment: biology and therapeutic targeting.

Author information

  • 1The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 428, Houston, TX 77030, USA. mkonople@mdanderson.org

Abstract

Acute myelogenous leukemia is propagated by a subpopulation of leukemia stem cells (LSCs). In this article, we review both the intrinsic and extrinsic components that are known to influence the survival of human LSCs. The intrinsic factors encompass regulators of cell cycle and prosurvival pathways (such as nuclear factor kappa B [NF-κB], AKT), pathways regulating oxidative stress, and specific molecular components promoting self-renewal. The extrinsic components are generated by the bone marrow microenvironment and include chemokine receptors (CXCR4), adhesion molecules (VLA-4 and CD44), and hypoxia-related proteins. New strategies that exploit potentially unique properties of the LSCs and their microenvironment are discussed.

PMID:
21220598
PMCID:
PMC4874213
DOI:
10.1200/JCO.2010.31.0904
[PubMed - indexed for MEDLINE]
Free PMC Article
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