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Structure. 2011 Jan 12;19(1):3-4. doi: 10.1016/j.str.2010.12.008.

EROS: Better than SAXS!

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1
Center for Proteomics and Department of Pharmacology, Case Western Reserve University, Biomedical Research Building, 10900 Euclid Avenue, Cleveland, OH 44106, USA. sichun.yang@case.edu

Abstract

Revealing the three-dimensional organization of large dynamic protein complexes in solution is challenging. To tackle this problem, Różycki and colleagues (2011) design a method combining small angle X-ray scattering (SAXS) data with the results of computer simulations. Their study offers new insights into the conformational transition induced by salt that occurs in an endosome-associated ESCRT-III CHMP3 domain.

PMID:
21220109
DOI:
10.1016/j.str.2010.12.008
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