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Annu Rev Immunol. 2011;29:215-33. doi: 10.1146/annurev-immunol-031210-101255.

Trafficking of B cell antigen in lymph nodes.

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1
The Immune Disease Institute and Program in Molecular and Cellular Medicine, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

The clonal selection theory first proposed by Macfarlane Burnet is a cornerstone of immunology (1). At the time, it revolutionized the thinking of immunologists because it provided a simple explanation for lymphocyte specificity, immunological memory, and elimination of self-reactive clones (2). The experimental demonstration by Nossal & Lederberg (3) that B lymphocytes bear receptors for a single antigen raised the central question of where B lymphocytes encounter antigen. This question has remained mostly unanswered until recently. Advances in techniques such as multiphoton intravital microscopy (4, 5) have provided new insights into the trafficking of B cells and their antigen. In this review, we summarize these advances in the context of our current view of B cell circulation and activation.

[Indexed for MEDLINE]

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