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Hypertens Pregnancy. 2012;31(1):79-90. doi: 10.3109/10641955.2010.525277. Epub 2011 Jan 10.

Standardized Mississippi Protocol treatment of 190 patients with HELLP syndrome: slowing disease progression and preventing new major maternal morbidity.

Author information

1
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, and the Biostatistics Center, University of Mississippi Medical Center, Jackson, MS 39216, USA. jnmartin@ob-gyn.umsmed.edu

Abstract

OBJECTIVE:

To evaluate the effectiveness of the Mississippi Protocol (MP) to treat HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.

METHODS:

Uniform early initiation of MP (corticosteroids, magnesium sulfate, systolic blood pressure control) was studied prospectively in patients admitted with severe preeclampsia/class 1 or class 2 HELLP syndrome.

RESULTS:

One hundred and ninety patients between 2000 and 2007 received MP without suffering maternal death, stroke, or liver rupture. Only 39 of 163 patients (24%) not class 1 when MP began progressed to class 1 disease; only 18.2% of class 1 and 2.4% of class 2 subsequently developed major maternal morbidity.

CONCLUSION:

Early initiation of MP inhibits HELLP syndrome disease progression and severity.

PMID:
21219123
DOI:
10.3109/10641955.2010.525277
[Indexed for MEDLINE]

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