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J Sci Food Agric. 2011 Feb;91(3):492-7. doi: 10.1002/jsfa.4211. Epub 2010 Nov 8.

Promising antifungal effect of some Euro-Asiatic plants against dangerous pathogenic and toxinogenic fungi.

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Crop Research Institute, Drnovsk√° 507, 161 06, Praha 6 Ruzyne, Czech Republic.



Increasing evidence of fungicide-resistant toxinogenic and pathogenic fungal species is obvious. Looking for new possibilities of antifungal treatment or sources of antifungal substances is a major problem. Some medicinal plants exert strong antifungal properties and could be conveniently used as a promising alternative source for presently problematic antifungal treatment in many areas with respect to their natural origin. Methanol extracts of 46 medicinal plants from the Eurasian area were used in a screening assay for antifungal activity in this study. The growth inhibitory effect was tested against six significant pathogenic and toxinogenic fungal species: Fusarium oxysporum, F. verticillioides, Penicillium expansum, P. brevicompactum, Aspergillus flavus and A. fumigatus.


For 14 plant species, the possibility of using them as natural fungicides was indicated. The extract from Grindelia camporum showed significant activity against all target fungal species. The most sensitive target fungus was the toxinogenic and human pathogenic species A. fumigatus.


This study has identified 14 extracts of medicinal plants with a potential use as an antifungal treatment in various areas. One of them showed promising efficiency against all selected significant pathogenic and toxinogenic fungal species.

[Indexed for MEDLINE]

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