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J Infect Dis. 2011 Feb 15;203(4):545-8. doi: 10.1093/infdis/jiq086. Epub 2011 Jan 7.

Impaired virulence and in vivo fitness of colistin-resistant Acinetobacter baumannii.

Author information

1
Servicio de Enfermedades Infecciosas, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Seville, Sevilla, Spain. rlopezrojas@hotmail.com

Abstract

Acinetobacter baumannii (American Type Culture Collection strain 19606) acquires mutations in the pmrB gene during the in vitro development of resistance to colistin. The colistin-resistant strain has lower affinity for colistin, reduced in vivo fitness (competition index, .016), and decreased virulence, both in terms of mortality (0% lethal dose, 6.9 vs 4.9 log colony-forming units) and survival in a mouse model of peritoneal sepsis. These results may explain the low incidence and dissemination of colistin resistance in A. baumannii in clinical settings.

PMID:
21216865
PMCID:
PMC3071218
DOI:
10.1093/infdis/jiq086
[Indexed for MEDLINE]
Free PMC Article

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