Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Biol. 2011 Jan 11;21(1):R40-7. doi: 10.1016/j.cub.2010.10.034.

Mechanism and significance of cis-inhibition in Notch signalling.

Author information

1
Institut Pasteur, Dépt. Biologie du Développement, F-75015 Paris, France.

Abstract

Notch receptors in a given cell are activated by cell surface ligands in neighbouring cells but can also be inhibited by the ligands present within the same cell. This process is known as cis-inhibition of Notch. Additionally, reciprocal cis-inhibition of the ligands by Notch has also been observed, albeit to a limited extent. Here, we review the mechanisms, functional relevance and potential implications of these cis-inhibitory interactions for Notch-mediated fate decisions.

PMID:
21215938
DOI:
10.1016/j.cub.2010.10.034
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center