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Cell. 2011 Jan 7;144(1):16-26. doi: 10.1016/j.cell.2010.11.056.

Epigenetics in alternative pre-mRNA splicing.

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  • 1National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Alternative splicing plays critical roles in differentiation, development, and disease and is a major source for protein diversity in higher eukaryotes. Analysis of alternative splicing regulation has traditionally focused on RNA sequence elements and their associated splicing factors, but recent provocative studies point to a key function of chromatin structure and histone modifications in alternative splicing regulation. These insights suggest that epigenetic regulation determines not only what parts of the genome are expressed but also how they are spliced.

PMID:
21215366
PMCID:
PMC3038581
DOI:
10.1016/j.cell.2010.11.056
[PubMed - indexed for MEDLINE]
Free PMC Article
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