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DNA Cell Biol. 2011 May;30(5):305-8. doi: 10.1089/dna.2010.1145. Epub 2011 Jan 8.

Association between interleukin-16 polymorphisms and risk of coronary artery disease.

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State Key Laboratory of Oral Disease, West China College of Stomatology, Sichuan University, Chengdu, China.


Growing evidence has shown that inflammation plays crucial roles in the development of coronary artery disease (CAD). Interleukin-16 (IL-16), a multifunctional cytokine, is involved in a series of inflammatory disorders. The aim of this study was to investigate the association between IL-16 polymorphisms and risk of CAD. We analyzed two polymorphisms of IL-16 (rs4778889 T/C and rs11556218 T/G) in 157 patients with CAD and 202 healthy controls by using polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing methods. The TG/GG genotypes of rs11556218 T/G were associated with a significantly increased risk of CAD as compared with the TT genotype (odds ratio = 1.77; 95% confidence intervals, 1.16-2.71). This finding indicates that IL-16 may be used as a genetic marker for CAD susceptibility.

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