Format

Send to

Choose Destination
Science. 2011 Feb 25;331(6020):1071-4. doi: 10.1126/science.1199424. Epub 2011 Jan 6.

Global tissue revolutions in a morphogenetic movement controlling elongation.

Author information

1
Department of Molecular and Cell Biology, 379 Life Sciences Addition no. 3200, University of California, Berkeley, Berkeley, CA 94720-3200, USA.

Abstract

Polarized cell behaviors drive axis elongation in animal embryos, but the mechanisms underlying elongation of many tissues remain unknown. Eggs of Drosophila undergo elongation from a sphere to an ellipsoid during oogenesis. We used live imaging of follicles (developing eggs) to elucidate the cellular basis of egg elongation. We find that elongating follicles undergo repeated rounds of circumferential rotation around their long axes. Follicle epithelia mutant for integrin or collagen IV fail to rotate and elongate, which results in round eggs. We present evidence that polarized rotation is required to build a polarized, fibrillar extracellular matrix (ECM) that constrains tissue shape. Thus, global tissue rotation is a morphogenetic behavior that uses planar polarity information in the ECM to control tissue elongation.

PMID:
21212324
PMCID:
PMC3153412
DOI:
10.1126/science.1199424
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center