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Eur J Pharmacol. 2011 Jun 11;660(1):2-12. doi: 10.1016/j.ejphar.2010.11.042. Epub 2011 Jan 3.

Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network.

Author information

1
Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

Over the past century, prevalent models of energy and glucose homeostasis have been developed from a better understanding of the neural circuits underlying obesity and diabetes. From the early hypothalamic lesion reports to the more recent pharmacological and molecular/genetic studies, the hypothalamic melanocortin system has been shown to play a critical role in the regulation of metabolism. This review attempts to highlight contributions to our current understanding of how numerous neuromodulators (leptin, insulin, and serotonin) integrate with the central melanocortin system to coordinate alterations in energy and glucose balance.

PMID:
21211525
PMCID:
PMC3085544
DOI:
10.1016/j.ejphar.2010.11.042
[Indexed for MEDLINE]
Free PMC Article

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