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Zhonghua Jie He He Hu Xi Za Zhi. 2010 Nov;33(11):831-6.

[Meta-analysis on interleukin-4 receptor α chain Q576R gene polymorphisms and bronchial asthma susceptibility].

[Article in Chinese]

Author information

1
Department of Respiratory Medicine, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.

Abstract

OBJECTIVE:

to study the association between interleukin-4 receptor α chain (IL-4RA) Q576R polymorphisms and bronchial asthma susceptibility by Meta-analysis.

METHODS:

four medical databases, including Pubmed, Embase, CNKI and Wanfang, were searched for the case-control studies about the IL-4RA polymorphisms and bronchial asthma susceptibility. Odds ratios (OR) of IL-4RA Q576R genotype distributions in asthma patients against healthy controls were analyzed in both RR vs QR + QQ model and QR + RR vs QQ model. Analyses were performed for asthma in general and for subgroups based on the atopy status of the asthma population. The sensitivity analysis and the publication bias tests were conducted.

RESULTS:

fifteen case-control studies, with 2675 asthma cases, 1202 atopic asthma cases and 331 nonatopic asthma cases respectively, were identified and all control group genotype frequencies were consistent with Hardy-Weinberg equilibrium. In genotype RR vs QR + QQ model no heterogeneity among the studies was found, while in genotype QR + RR vs QQ model, heterogeneity among these studies was found. These studies were analyzed by fixed-effect model (RR vs QR + QQ model) or random-effect model (QR + RR vs QQ model). The pooled odds ratio of IL-RA Q576R genotype RR vs QR + QQ was 2.02 (95%CI: 1.53 - 2.66), and the pooled odds ratio in this model in the atopic asthma subgroup was 2.26 (95%CI: 1.47 - 3.49), while the pooled odds ratio (QR + RR vs QQ model) was 1.02 (95%CI: 1.06 - 1.53).

CONCLUSION:

a meta-analysis of results from case-control studies strongly supports the conclusion that IL-4RA Q576R polymorphisms impart a modest yet significant risk for asthma.

PMID:
21211370
[Indexed for MEDLINE]
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