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Acta Neurol Taiwan. 2010 Dec;19(4):263-9.

Gluten sensitivity: associated sporadic cerebellar ataxia in Taiwan.

Author information

1
Department of Neurology, Vascular and Genomics Center, Changhua Christian Hospital, No. 135, Nanhsiao Street, Changhua 500, Taiwan. 26602@cch.org.tw

Abstract

PURPOSE:

Gluten sensitivity (GS) is related to the pathogenesis of sporadic or hereditary ataxia.

METHODS:

Total of 194 healthy controls and patients with either hereditary ataxia (n=207) or sporadic ataxia (n=361) were tested for the circulating gluten-related autoantibodies which serve as biomarkers to interpret the existence of GS.

RESULTS:

The incidences of GS in each population were 1% in normal subjects, 2% in hereditary ataxia patients and 9% in sporadic ataxia patients. High serum level of anti-gliadin IgG/IgA and t-transglutaminase IgA were disclosed at the sporadic ataxia patients compared with normal subjects. However, the anti-gliadin IgG is more specific to the disease of sporadic ataxia.

CONCLUSION:

Relatively higher incidence of GS was found in the population of sporadic ataxia patients but not in either normal subjects or hereditary ataxia patients in Taiwan. Anti-gliadin IgG still is a very powerful indicator to implicate the immune-related sporadic ataxia and we conclude that GS-related sporadic ataxia exists in Taiwan with linkage to autoimmune events.

PMID:
21210327
[Indexed for MEDLINE]

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