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Cold Spring Harb Symp Quant Biol. 2010;75:43-9. doi: 10.1101/sqb.2010.75.020. Epub 2011 Jan 5.

Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation.

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Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.


The influence of histone amino-terminal covalent modifications on gene regulation has drawn intense research efforts in recent years. It is now clear that activating and inactivating modifications have a key role in determining the gene-expression profile of an individual cell or cell lineage. Thus, differences in these modifications have a pivotal role in determining and maintaining cell fate during development. The interplay of histone methyltransferases (HMTs) and demethylases confers the plasticity necessary for changes in the gene-expression profile of a cell during differentiation or changes following environmental cues. The histone H3 lysine 27 (H3K27) demethylases Jmjd3 and UTX remove the gene-inactivating H3K27 dimethyl and trimethyl marks and are involved in inducing and/or maintaining gene expression. In this chapter, we highlight the role of the H3K27 demethylases Jmjd3 and UTX in gene expression.

[Indexed for MEDLINE]

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