[The changes of coagulation and fibrinolysis function on hypoxia adaptation mechanism]

Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2001 Nov;17(4):363-5.
[Article in Chinese]

Abstract

Aim and methods: To determine their Antithrombin-III (AT-III), Plasminogen (PLG), D-Dimer (DD), tissue-Plasminogen Activator (t-PA), Plasminogen Activator Inhibitor (PAI), Fibrinogen (Fg) and alpha2-Plasmin, inhibitor (alpha2-PI), when 40 subjects entered to high altitude, and compared with healthy flatlander.

Results: At high altitude (3 700 m, 5 380 m) the AT-III abd t-PA were lower significantly than that of the flatlander (1 400m) (P < 0.05 or P < 0.01). The higher altitude subjects enter, the lower count will take (P < 0.01), and with the longer stay time, there was a higher count (P < 0.05 or P < 0.01). The 7th day at high altitude, PLG. DD. PAI. alpha2-PI and Fg were much higher than the flatlander's (P < 0.05 or P < 0.01), and with the higher elevation, there were higher datas, and with the longer stay time, there were lower datas (P < 0.05 or P < 0.01). Compare the a half of year at 3 700m with the flatlands, the results isn't discrepant (P > 0.05).

Conclusion: There is a coagulation-function disorder at high altitude, the results shows that coagulation and fibrinolysis are activated and fibrinolysis is inhibited yet, so the coagulation-fibrinolysis balance is destroyed. This effects lead to a hypercoagulation and hypo fibrinolysis state.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Altitude*
  • Antithrombin III / analysis
  • Blood Coagulation / physiology*
  • Fibrin Fibrinogen Degradation Products / analysis
  • Fibrinogen / analysis
  • Fibrinolysin / analysis
  • Fibrinolysis / physiology*
  • Humans
  • Hypoxia*
  • Male
  • Plasminogen Activator Inhibitor 1 / analysis
  • Tissue Plasminogen Activator / analysis
  • Young Adult
  • alpha-2-Antiplasmin / analysis

Substances

  • Fibrin Fibrinogen Degradation Products
  • Plasminogen Activator Inhibitor 1
  • alpha-2-Antiplasmin
  • fibrin fragment D
  • plasmin-plasmin inhibitor complex
  • Antithrombin III
  • Fibrinogen
  • Tissue Plasminogen Activator
  • Fibrinolysin