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Cell Mol Life Sci. 2011 Apr;68(8):1395-403. doi: 10.1007/s00018-010-0613-2. Epub 2011 Jan 5.

Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeast.

Author information

1
Division of Cytogenetics, National Institute of Genetics/The Graduate University for Advanced Studies, SOKENDAI, 1111 Yata, Mishima, Shizuoka, Japan. takobaya@lab.nig.ac.jp

Abstract

The genes encoding ribosomal RNA (rRNA) are the most abundant genes in the eukaryotic genome. They reside in tandem repetitive clusters, in some cases totaling hundreds of copies. Due to their repetitive structure and highly active transcription, the rRNA gene repeats are some of the most fragile sites in the chromosome. A unique gene amplification system compensates for loss of copies, thus maintaining copy number, albeit with some fluctuations. The unusual nature of rRNA gene repeats affects cellular functions such as senescence. In addition, we recently found that the repeat number determines sensitivity to DNA damage. In this review, I would like to introduce a new aspect of the rRNA gene repeat (called rDNA) as a center of maintenance of genome integrity and discuss its contribution to evolution.

PMID:
21207101
PMCID:
PMC3064901
DOI:
10.1007/s00018-010-0613-2
[Indexed for MEDLINE]
Free PMC Article

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