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Indian J Pharmacol. 2010 Oct;42(5):283-8. doi: 10.4103/0253-7613.70108.

Effects of Ocimum sanctum and Camellia sinensis on stress-induced anxiety and depression in male albino Rattus norvegicus.

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1
Department of Chemistry, J.N. Medical College, Aligarh Muslim University, Aligarh - 202 002, UP, India.

Abstract

OBJECTIVE:

The aim of this study was to study the ameliorative effects of Ocimum sanctum and Camellia sinensis on stress-induced anxiety and depression.

MATERIALS AND METHODS:

The study was carried out using male albino rats (200 ± 50 g). The effect of O. sanctum and C. sinensis was evaluated for anxiety and depression using elevated plus maze (EPM) test, open field test (OFT), forced swim test (FST), and tail suspension test (TST).

RESULT:

Restraint stress (3 h/day for six consecutive days) induced a significant reduction in both the percentage number of entries and time spent in open arms in EPM, and these changes were reversed with post-treatment of aqueous extract of O. sanctum and C. sinensis (100 mg/kg for 6 days). Restraint stress-induced (a) increased latency and (b) decreased ambulation and rearing were also reversed by O. sanctum and C. sinensis in OFT. A significant increase in immobility period was observed in FST and TST after restraint stress. O. sanctum and C. sinensis significantly reduced the immobility times of rats in FST and TST.

CONCLUSION:

O. sanctum and C. sinensis possess anxiolytic and antidepressant activities.

KEYWORDS:

Anxiety; Camellia sinensis; Ocimum sanctum; depression; restraint stress

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