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Pediatr Infect Dis J. 2011 Jul;30(7):608-10. doi: 10.1097/INF.0b013e3182093814.

Effect of a prepregnancy pertussis booster dose on maternal antibody titers in young infants.

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Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, WHO Collaborating Centre for Control and Prevention of Infectious Diseases, Faculty of Medicine, University of Antwerp, Antwerp, Belgium.


To examine the influence of a pertussis booster vaccination on the transfer of maternal antibodies, 24 nonpregnant women received a tetanus, diphtheria, acellular pertussis booster vaccine between 2 consecutive pregnancies. Blood was drawn from mothers and off-spring. Efficient transplacental antibody transfer and significantly higher antibody titers against 3 pertussis antigens were observed in cord blood and in blood of 1-month-old infants born after a maternal booster vaccination compared with results in their siblings born before the booster administration.

[Indexed for MEDLINE]

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