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Cancer Prev Res (Phila). 2011 Jan;4(1):1-5. doi: 10.1158/1940-6207.CAPR-10-0345.

The search for unaffected individuals with Lynch syndrome: do the ends justify the means?

Author information

1
Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 2001 Polaris Parkway, Columbus, OH 43240, USA. Heather.Hampel@osumc.edu

Abstract

Lynch syndrome is the most common cause of inherited colorectal and endometrial cancers yet it is underrecognized in clinical practice. The relative merits of screening for Lynch syndrome among healthy adults without cancer versus among adults with colorectal or endometrial cancer are discussed in this Perspective article. Newly diagnosed colorectal cancer patients are a much easier target population for screening and this approach leads to more informative genetic test results, at a lower cost in most cases.

PMID:
21205737
PMCID:
PMC3076593
DOI:
10.1158/1940-6207.CAPR-10-0345
[Indexed for MEDLINE]
Free PMC Article

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