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Epidemiol Infect. 2011 Nov;139(11):1676-86. doi: 10.1017/S0950268810002839. Epub 2010 Dec 17.

Risk factors for symptomatic and asymptomatic norovirus infection in the community.

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1
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK. g.phillips@uel.ac.uk

Abstract

The objective of this study was to investigate risk factors for norovirus-associated infectious intestinal disease (IID) and asymptomatic norovirus infection. Individuals with IID and healthy controls were recruited in a community-based study in England (1993-1996). This is the first risk-factor study to use viral load measurements, generated by real-time RT-PCR, to identify cases of norovirus-associated IID and asymptomatic infections. Using multivariable logistic regression the main risk factor identified for norovirus-associated IID was contact with a person with IID symptoms. Infectious contacts accounted for 54% of norovirus cases in young children and 39% of norovirus cases in older children and adults. For young children, contacts outside the household presented the highest risk; for older children and adults, the highest risk was associated with child contacts inside the household. Foreign travel and consumption of shellfish increased the risk of norovirus-associated IID. Lifestyle and dietary factors were associated with a decreased risk of both norovirus-associated IID and asymptomatic infection. No risk factors were identified for asymptomatic norovirus infection.

PMID:
21205382
DOI:
10.1017/S0950268810002839
[Indexed for MEDLINE]
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