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Proteomics. 2011 Jan;11(2):329-33. doi: 10.1002/pmic.201000454. Epub 2010 Dec 17.

A QconCAT informatics pipeline for the analysis, visualization and sharing of absolute quantitative proteomics data.

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  • 1Manchester Centre for Integrative Systems Biology, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, UK.


Absolute protein concentration determination is becoming increasingly important in a number of fields including diagnostics, biomarker discovery and systems biology modeling. The recently introduced quantification concatamer methodology provides a novel approach to performing such determinations, and it has been applied to both microbial and mammalian systems. While a number of software tools exist for performing analyses of quantitative data generated by related methodologies such as SILAC, there is currently no analysis package dedicated to the quantification concatamer approach. Furthermore, most tools that are currently available in the field of quantitative proteomics do not manage storage and dissemination of such data sets.

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