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Protein Cell. 2010 Oct;1(10):907-15. doi: 10.1007/s13238-010-0121-z. Epub 2010 Nov 9.

The late stage of autophagy: cellular events and molecular regulation.

Author information

1
State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Science, Tsinghua University, Beijing 100084, China.

Abstract

Autophagy is an intracellular degradation system that delivers cytoplasmic contents to the lysosome for degradation. It is a "self-eating" process and plays a "house-cleaner" role in cells. The complex process consists of several sequential steps-induction, autophagosome formation, fusion of lysosome and autophagosome, degradation, efflux transportation of degradation products, and autophagic lysosome reformation. In this review, the cellular and molecular regulations of late stage of autophagy, including cellular events after fusion step, are summarized.

PMID:
21204017
PMCID:
PMC4875124
DOI:
10.1007/s13238-010-0121-z
[Indexed for MEDLINE]
Free PMC Article

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