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Protein Cell. 2010 Sep;1(9):820-9. doi: 10.1007/s13238-010-0104-0. Epub 2010 Oct 7.

Nucleosome assembly and epigenetic inheritance.

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1
Graduate Program, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.

Abstract

In eukaryotic cells, histones are packaged into octameric core particles with DNA wrapping around to form nucleosomes, which are the basic units of chromatin (Kornberg and Thomas, 1974). Multicellular organisms utilise chromatin marks to translate one single genome into hundreds of epigenomes for their corresponding cell types. Inheritance of epigenetic status is critical for the maintenance of gene expression profile during mitotic cell divisions (Allis et al., 2006). During S phase, canonical histones are deposited onto DNA in a replication-coupled manner (Allis et al., 2006). To understand how dividing cells overcome the dilution of epigenetic marks after chromatin duplication, DNA replication coupled (RC) nucleosome assembly has been of great interest. In this review, we focus on the potential influence of RC nucleosome assembly processes on the maintenance of epigenetic status.

PMID:
21203924
PMCID:
PMC4875226
DOI:
10.1007/s13238-010-0104-0
[Indexed for MEDLINE]
Free PMC Article
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