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J Clin Invest. 1990 Oct;86(4):1369-74.

In vivo activation by ultraviolet rays of the human immunodeficiency virus type 1 long terminal repeat.

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Unité 152 Institut Cochin de Génétique Moléculaire, Institut National de la Santé et de la Recherche Medical, Paris, France.


It has been previously shown in vitro that the human immunodeficiency virus type 1 long terminal repeat (LTR) is activated by ultraviolet irradiation. In order to analyze if a similar effect could occur in vivo, transgenic mice carrying the lacZ gene under the control of the viral LTR were irradiated at 280-300 and 254 nm. These mice spontaneously expressed the transgene in the epidermis and the lens of both adults and embryos. Irradiations caused a significant increase in skin beta-galactosidase activity. This phenomenon might be involved in viral activation and could be of interest in regard to the skin pathology observed during an HIV infection.

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