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Clin Endocrinol (Oxf). 2011 Apr;74(4):513-9. doi: 10.1111/j.1365-2265.2010.03974.x.

Thyroid autoimmunity and miscarriage: a meta-analysis.

Author information

1
Department of Endocrinology, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, Shanghai, P. R. China.

Abstract

OBJECTIVE:

To investigate whether thyroid autoimmunity (TAI) is associated with increased risk of miscarriage in euthyroid women.

METHODS:

An electronic search was conducted using the databases Medline, PubMed, EMBASE and the Cochrane library, from inception to October 2010. A systematic review of the studies on the association between TAI and miscarriage was performed. The odd ratios of case-control studies and relative risks of cohort studies were pooled respectively. The software Review Manager (version 4.3.1) was applied for meta-analysis.

RESULTS:

The search strategy identified 53 potentially relevant publications, 22 of which were included in the meta-analysis. A clear association between thyroid autoimmunity and miscarriage was observed with a pooled odds ratio of 2·55 (95% CI 1·42-4·57, P=0·002) in eight case-control studies and a pooled relative risk of 2·31 (95% CI 1·90-2·82, P<0·000 01) in 14 cohort studies. Women with TAI were found to have slightly higher age [age difference, 1·29 years] (95% CI 0·43-2·16, P=0·003) and thyroid-stimulating hormone (TSH) levels [TSH difference, 0·61 mIU/l] (95% CI 0·51-0·71, P<0·000 01) compared with those without TAI.

CONCLUSION:

Based on the currently available evidence, it appears that the presence of thyroid autoimmunity is associated with an increased risk of spontaneous miscarriage in euthyroid women.

[Indexed for MEDLINE]

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