Format

Send to

Choose Destination
See comment in PubMed Commons below
J Biomed Biotechnol. 2011;2011:609813. doi: 10.1155/2011/609813. Epub 2010 Dec 13.

Perinatal hypoxic-ischemic encephalopathy.

Author information

1
Department of Pediatrics, Chi Mei Medical Center, Tainan, Taiwan.

Abstract

Perinatal hypoxic-ischemic encephalopathy (HIE) is an important cause of brain injury in the newborn and can result in long-term devastating consequences. Perinatal hypoxia is a vital cause of long-term neurologic complications varying from mild behavioural deficits to severe seizure, mental retardation, and/or cerebral palsy in the newborn. In the mammalian developing brain, ongoing research into pathophysiological mechanism of neuronal injury and therapeutic strategy after perinatal hypoxia is still limited. With the advent of promising therapy of hypothermia in HIE, this paper reviews the pathophysiology of HIE and the future potential neuroprotective strategies for clinical potential for hypoxia sufferers.

PMID:
21197402
PMCID:
PMC3010686
DOI:
10.1155/2011/609813
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Hindawi Publishing Corporation Icon for PubMed Central
    Loading ...
    Support Center