Format

Send to

Choose Destination
Nat Chem Biol. 2011 Feb;7(2):78-80. doi: 10.1038/nchembio.509. Epub 2011 Jan 2.

Sublancin is not a lantibiotic but an S-linked glycopeptide.

Author information

1
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

Abstract

Sublancin is shown to be an S-linked glycopeptide containing a glucose attached to a cysteine residue, establishing a new post-translational modification. The activity of the S-glycosyl transferase was reconstituted in vitro, and the enzyme is shown to have relaxed substrate specificity, allowing the preparation of analogs of sublancin. Glycosylation is essential for its antimicrobial activity.

PMID:
21196935
PMCID:
PMC3060661
DOI:
10.1038/nchembio.509
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center