Format

Send to

Choose Destination
Front Biosci (Landmark Ed). 2011 Jan 1;16:1-12.

Is insulin resistance a disorder of the brain?

Author information

1
Jawaharlal Nehru Technological University, Kakinada 533 003, India. undurti@hotmail.com

Abstract

There is reasonable evidence to suggest that insulin resistance may have its origins in the hypothalamus. Insulin secretion is regulated by sympathetic and parasympathetic nervous systems and modulates the concentrations of hypothalamic neuropeptides and monoaminergic neurotransmitters, and, in return, hypothalamic monoamines regulate the secretion of insulin by pancreatic beta cells. A lesion of the ventromedial hypothalamus produces all the features of the metabolic syndrome including insulin resistance and hyperinsulinemia. These and other evidence suggest that insulin resistance may very well be a disease of the brain.

PMID:
21196154
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Frontiers in Bioscience
Loading ...
Support Center