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Biol Blood Marrow Transplant. 2011 Jan;17(1 Suppl):S15-20. doi: 10.1016/j.bbmt.2010.09.019.

Genetic modification of T cells.

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1
Experimental Hematology Unit, Research Division of Regenerative Medicine, Gene Therapy and Stem Cells, Hematology and BMT Unit, Department of Oncology, San Raffaele Scientific Institute, Milano, Italy.

Abstract

Adoptively transferred T cells have shown activity in treating viral infections after hemopoietic transplantation and anti-tumor activity against some malignancies such as melanoma and lymphoma. Current research focuses on defining the optimum type of cell for transfer to improve persistence and genetically modifying infused T cells to augment function, overcome tumor evasion strategies and allow ablation should adverse effects occur.

PMID:
21195304
PMCID:
PMC3053011
DOI:
10.1016/j.bbmt.2010.09.019
[Indexed for MEDLINE]
Free PMC Article
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