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J Cyst Fibros. 2011 Mar;10(2):100-6. doi: 10.1016/j.jcf.2010.11.001. Epub 2010 Dec 30.

The impact of nocturnal oxygen desaturation on quality of life in cystic fibrosis.

Author information

1
Department of Allergy Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, Victoria, 3004, Australia. a.young@alfred.org.au

Abstract

BACKGROUND:

Nocturnal oxyhaemoglobin desaturation is common in cystic fibrosis (CF) but the effect on quality of life (QoL) remains unknown.

METHODS:

Sixty stable CF outpatients with mean age 31±8 years (mean±1 SD), BMI 20.8±3.2 kg/m(2) and FEV(1) 42±13% predicted had arterial blood gas sampling, lung function testing, overnight pulse oximetry and completed the CF QoL questionnaire, Epworth Sleepiness Scale and Medical Research Council dyspnoea scale.

RESULTS:

11 (18%) of the CF patients were 'desaturators,' (SpO(2)<90% for ≥30% recording time on overnight oximetry). Desaturators had greater difficulty performing their treatments (39±22 vs 61±26, p<0.01) and more exertional dyspnoea (3.2±0.8 vs 2.0±0.9, p<0.001) than non-desaturators after controlling for the effects of FEV(1), awake PaO(2) and PaCO(2) (adjusted p-values <0.01 and 0.04 respectively).

CONCLUSIONS:

Nocturnal oxyhaemoglobin desaturation is associated with impaired QoL, independent of the effects of lung function and awake gas exchange, in stable CF outpatients with moderate to severe lung disease.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00157183.

PMID:
21195036
DOI:
10.1016/j.jcf.2010.11.001
[Indexed for MEDLINE]
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