Format

Send to

Choose Destination
IEEE Trans Image Process. 2011 Jul;20(7):1925-37. doi: 10.1109/TIP.2010.2099125. Epub 2010 Dec 30.

3-D active meshes: fast discrete deformable models for cell tracking in 3-D time-lapse microscopy.

Author information

1
Institut Pasteur, Quantitative Image Analysis Unit, Paris, France.

Abstract

Variational deformable models have proven over the past decades a high efficiency for segmentation and tracking in 2-D sequences. Yet, their application to 3-D time-lapse images has been hampered by discretization issues, heavy computational loads and lack of proper user visualization and interaction, limiting their use for routine analysis of large data-sets. We propose here to address these limitations by reformulating the problem entirely in the discrete domain using 3-D active meshes, which express a surface as a discrete triangular mesh, and minimize the energy functional accordingly. By performing computations in the discrete domain, computational costs are drastically reduced, whilst the mesh formalism allows to benefit from real-time 3-D rendering and other GPU-based optimizations. Performance evaluations on both simulated and real biological data sets show that this novel framework outperforms current state-of-the-art methods, constituting a light and fast alternative to traditional variational models for segmentation and tracking applications.

PMID:
21193379
DOI:
10.1109/TIP.2010.2099125
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for IEEE Engineering in Medicine and Biology Society
Loading ...
Support Center