Format

Send to

Choose Destination
Int J Geriatr Psychiatry. 2011 Nov;26(11):1101-8. doi: 10.1002/gps.2668. Epub 2010 Dec 29.

MRI-defined vascular depression: a review of the construct.

Author information

1
The Graduate Center, City University of New York, NY, USA.

Abstract

OBJECTIVE:

To review the construct of MRI-defined vascular depression and to examine the substantive and methodological issues that bear on its validity as a distinct subtype of depression in late life.

DESIGN:

Literature review.

RESULTS:

We identified three areas that are critical to establishing the validity of MRI-defined vascular depression: (1) understanding and delineating the relationship between MRI hyperintensities, executive dysfunction, and antidepressant treatment outcome; (2) understanding the relationship between, and establishing the validity of, qualitative and quantitative approaches to the measurement of MRI hyperintensities (the primary feature of the proposed subtype); (3) establishing the clinical presentation and course of the subtype in the context of other late-life disorders.

CONCLUSIONS:

Despite considerable data supporting the validity of MRI-defined vascular depression, there are a number of critical issues that remain, including establishing a causal relationship between cerebrovascular disease and late-life depression, establishing consistent diagnostic criteria, determining the importance of lesion type and location, and understanding the course of the disorder.

PMID:
21192018
DOI:
10.1002/gps.2668
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center