Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2011 Jan 15;21(2):805-11. doi: 10.1016/j.bmcl.2010.11.098. Epub 2010 Nov 25.

Structure based evolution of a novel series of positive modulators of the AMPA receptor.

Author information

1
Merck Research Laboratories, MSD, Newhouse, Motherwell, Lanarkshire ML1 5SH, UK. craig.jamieson@strath.ac.uk

Abstract

Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotype with a promising overall profile, exemplified by 19.

PMID:
21190850
DOI:
10.1016/j.bmcl.2010.11.098
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science Icon for Strathprints - the University of Strathclyde
Loading ...
Support Center