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Biophys J. 2011 Jan 5;100(1):80-9. doi: 10.1016/j.bpj.2010.11.002.

Near-critical fluctuations and cytoskeleton-assisted phase separation lead to subdiffusion in cell membranes.

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1
Biophysics, BIOTEC, Technische Universität Dresden, Dresden, Germany.

Abstract

We address the relationship between membrane microheterogeneity and anomalous subdiffusion in cell membranes by carrying out Monte Carlo simulations of two-component lipid membranes. We find that near-critical fluctuations in the membrane lead to transient subdiffusion, while membrane-cytoskeleton interaction strongly affects phase separation, enhances subdiffusion, and eventually leads to hop diffusion of lipids. Thus, we present a minimum realistic model for membrane rafts showing the features of both microscopic phase separation and subdiffusion.

PMID:
21190659
PMCID:
PMC3010007
DOI:
10.1016/j.bpj.2010.11.002
[Indexed for MEDLINE]
Free PMC Article
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