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Behav Brain Funct. 2010 Dec 29;6:75. doi: 10.1186/1744-9081-6-75.

Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese.

Author information

1
Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China.

Abstract

BACKGROUND:

The NADH-ubiquinone oxidoreductase flavoprotein gene (NDUFV2), which encodes a 24 kD mitochondrial complex I subunit, has been reported to be positively associated with schizophrenia and bipolar disorder in different populations.

METHODS:

We genotyped the promoter variants of this gene (rs6506640 and rs1156044) by direct sequencing in 529 unrelated Han Chinese schizophrenia patients and 505 matched controls. Fisher's Exact test was performed to assess whether these two reported single nucleotide polymorphisms (SNPs) confer susceptibility to schizophrenia in Chinese.

RESULTS:

Allele, genotype and haplotype comparison between the case and control groups showed no statistical significance, suggesting no association between the NDUFV2 gene promoter variants and schizophrenia in Han Chinese.

CONCLUSION:

The role of NDUFV2 played in schizophrenia needs to be further studied. Different racial background and/or population substructure might account for the inconsistent results between studies.

PMID:
21190551
PMCID:
PMC3022841
DOI:
10.1186/1744-9081-6-75
[Indexed for MEDLINE]
Free PMC Article
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