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Autophagy. 2011 Apr;7(4):434-5. Epub 2011 Apr 1.

Cardioprotection through autophagy: ready for clinical trial?

Author information

1
Radical Therapeutix, Inc., Solana Beach, CA, USA. rgottlieb@radicaltx.com

Abstract

Interventions that reduce infarct size in animal models have largely failed to improve outcome in patients suffering acute myocardial infarction (MI), or 'heart attack'. Our group recently reported a reduction of infarct size by chloramphenicol treatment in a porcine in vivo model of acute MI, through a mechanism involving the induction of autophagy. Since 2005 several studies have implicated autophagy as a target for cardioprotection.

PMID:
21187717
PMCID:
PMC3127222
[Indexed for MEDLINE]
Free PMC Article
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