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Am J Med. 2011 Jan;124(1):85.e1-8. doi: 10.1016/j.amjmed.2010.08.005.

Effects of alpha-lipoic Acid on body weight in obese subjects.

Author information

1
Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Abstract

PURPOSE:

alpha-lipoic acid is an essential cofactor for mitochondrial respiratory enzymes that improves mitochondrial function. We previously reported that alpha-lipoic acid markedly reduced body weight gain in rodents. The purpose of this study was to determine whether alpha-lipoic acid reduces body weight in obese human subjects.

METHODS:

in this randomized, double-blind, placebo-controlled, 20-week trial, 360 obese individuals (body mass index [BMI] ≥ 30 kg/m(2) or BMI 27-30 kg/m(2) plus hypertension, diabetes mellitus, or hypercholesterolemia) were randomized to alpha-lipoic acid 1200 or 1800 mg/d or placebo. The primary end point was body weight change from baseline to end point.

RESULTS:

the 1800 mg alpha-lipoic acid group lost significantly more weight than the placebo group (2.1%; 95% confidence interval, 1.4-2.8; P<.05). Urticaria and itching sensation were the most common adverse events in the alpha-lipoic acid groups, but these were generally mild and transient.

CONCLUSION:

alpha-lipoic acid 1800 mg/d led to a modest weight loss in obese subjects. Alpha-lipoic acid may be considered as adjunctive therapy for obesity.

PMID:
21187189
DOI:
10.1016/j.amjmed.2010.08.005
[Indexed for MEDLINE]

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