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Int J Biochem Cell Biol. 2011 Apr;43(4):470-3. doi: 10.1016/j.biocel.2010.12.020. Epub 2010 Dec 25.

ZNF224: Structure and role of a multifunctional KRAB-ZFP protein.

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  • 1Dipartimento di Biochimica e Biotecnologie Mediche, Universit√† di Napoli Federico II, Via S. Pansini 5, 80131 Napoli, Italy.


The Kruppel-like zinc finger protein ZNF224 was originally identified as the transcriptional repressor of the human aldolase A gene. ZNF224 transcriptional repression depends on interaction with the corepressor KAP-1 and the recruitment of enzyme activities modifying chromatin, in accordance with repression mechanism of KRAB-ZFP family. Recently, the arginine methyltransferase PRMT5 was demonstrated to play a crucial role in the transcriptional ZNF224 repressor complex. An alternatively spliced isoform, ZNF255, arises from the ZNF224 gene. ZNF224 and ZNF255 have a distinct pattern of distribution within the cell and display a specific pattern of interaction with different molecular partners. These isoform-specific interactions seem to control different cellular pathways. These findings suggest that ZNF224 is a multifunctional protein and that alternative splicing, sub-cellular compartmentalization and isoform-specific interactions may modulate its activity.

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