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J Ethnopharmacol. 2011 Mar 24;134(2):504-9. doi: 10.1016/j.jep.2010.12.012. Epub 2010 Dec 22.

Inhibition of 2,4-dinitrofluorobenzene-induced atopic dermatitis by topical application of the butanol extract of Cordyceps bassiana in NC/Nga mice.

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1
Department of Physiology, College of Medicine, Hallym University, 39 Hallymdaehak-gil, Chuncheon 200-702, Republic of Korea.

Abstract

ETHNOPHARMACOLOGICAL SIGNIFICANCE:

The Cordyceps species are insect-borne mushrooms that have been ethnopharmacologically used for skin diseases such as eczema and dermatitis.

AIM OF THE STUDY:

In this study, we investigated the curative effects of the butanol fraction (CBBF) of Cordyceps bassiana on atopic dermatitis.

MATERIALS AND METHODS:

Dermatitis was induced by repeated application of 2,4-dinitrofluorobenzene (DNFB) in NC/Nga mice. After a topical application of CBBF on the skin lesions, the dermatitis score, epidermal thickness, mast cell number, and interleukin (IL)-4 and interferon (IFN)-γ, as well as the levels of histamine and immunoglobulin E (IgE) in the serum, were measured. Moreover, effect of CBBF on histamine release was examined using RBL-2H3 under stimulation with 2,4-dinitrophenylated bovine serum albumin (DNP-BSA).

RESULTS:

CBBF inhibited atopic dermatitis symptoms and signs in the DNFB-treated NC/Nga mice. The suppressive activity of topically applied CBBF may be due to the dose-dependent blockade of a series of immunopathological events, including the release of histamine, the production of IgE, and the secretion of IL-4 and IFN-γ. However, this extract did not directly suppress the degranulation process, assessed by measuring β-hexosaminidase release.

CONCLUSIONS:

Our results suggest that CBBF can be applied as an effective herbal remedy to treat atopic dermatitis.

PMID:
21184821
DOI:
10.1016/j.jep.2010.12.012
[Indexed for MEDLINE]

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