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Behav Brain Res. 2011 Apr 15;218(2):346-9. doi: 10.1016/j.bbr.2010.12.017. Epub 2010 Dec 22.

Alcohol seeking and consumption in the NVHL neurodevelopmental rat model of schizophrenia.

Author information

1
Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202, USA. saberg@iupui.edu

Abstract

Alcohol abuse in schizophrenia exceeds rates in the general population and worsens illness outcomes. Neonatal ventral hippocampal lesion (NVHL) rats model multiple schizophrenia dimensions including addiction vulnerability. This study compared NVHL vs. SHAM-controls in operant alcohol seeking and consumption. NVHLs enhanced consumption of combined ethanol/sucrose solution but neither ethanol or sucrose only solutions, consistent with increased vulnerability specific to carbohydrate-laden alcohol beverages typically consumed in early stages of human alcoholism.

PMID:
21184782
PMCID:
PMC3040447
DOI:
10.1016/j.bbr.2010.12.017
[Indexed for MEDLINE]
Free PMC Article

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