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Cell Biochem Biophys. 2011 Jul;60(3):137-54. doi: 10.1007/s12013-010-9137-5.

The structure and function of endophilin proteins.

Author information

1
Department of Neuroscience and Pharmacology, University of Copenhagen, 2200 Copenhagen, Denmark. okjaerulff@sund.ku.dk

Abstract

Members of the BAR domain protein superfamily are essential elements of cellular traffic. Endophilins are among the best studied BAR domain proteins. They have a prominent function in synaptic vesicle endocytosis (SVE), receptor trafficking and apoptosis, and in other processes that require remodeling of the membrane structure. Here, we discuss the role of endophilins in these processes and summarize novel insights into the molecular aspects of endophilin function. Also, we discuss phosphorylation of endophilins and how this and other mechanisms may contribute to disease.

PMID:
21184288
DOI:
10.1007/s12013-010-9137-5
[Indexed for MEDLINE]

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