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Int J Obstet Anesth. 2011 Apr;20(2):178-80. doi: 10.1016/j.ijoa.2010.10.007. Epub 2010 Dec 22.

Anaesthetic management of a patient with Liddle's syndrome for emergency caesarean hysterectomy.

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Department of Anaesthesia, Rotunda Hospital, Dublin, Ireland.


We describe the anaesthetic management of a patient with Liddle's syndrome during caesarean section and emergency hysterectomy for placenta accreta associated with significant intrapartum haemorrhage. Liddle's syndrome is a rare autosomal dominant disorder characterised by early onset arterial hypertension and hypokalaemic metabolic alkalosis. Additional issues were the presence of short stature, limb hypertonicity and preeclampsia. Initial management with a low-dose combined spinal-epidural technique was subsequently converted to general anaesthesia due to patient discomfort. The management of Liddle's syndrome in the setting of neuraxial and general anaesthesia in a patient undergoing caesarean section is discussed.

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