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J Ethnopharmacol. 2011 Mar 24;134(2):294-7. doi: 10.1016/j.jep.2010.12.019. Epub 2010 Dec 21.

Gastric antisecretory and antiulcer activities of Cedrus deodara (Roxb.) Loud. in Wistar rats.

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1
School of Pharmaceutical Sciences, Shobhit University, NH-58, Modipuram, Meerut 250110, UP, India.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Cedrus deodara (Roxb.) Loud. is used in Ayurvedic medicine to treat peptic ulcer.

AIM OF THE STUDY:

To evaluate the gastric antisecretory and antiulcer activity of Cedrus deodara.

MATERIALS AND METHODS:

The volatile oil extracted by steam distillation of Cedrus deodara wood was examined for its gastric antisecretory and antiulcer effect in the pylorus-ligated rat model and ethanol induced gastric lesions in rats.

RESULTS:

The volatile oil showed significant antisecretory activity as evidenced by decreased gastric fluid volume, total acidity, free acidity and increase in the pH of the gastric fluid in pylorus-ligated rats. Our studies also revealed that pretreatment with Cedrus deodara significantly reduced the number of ulcer, ulcer score and ulcer index in pylorus-ligated and ethanol treated rats. The antiulcer activity of Cedrus deodara is further supported by histopathological study which showed protection of mucosal layer from ulceration and inflammation.

CONCLUSION:

The present findings conclude that volatile oil of Cedrus deodara wood has potent antisecretory and antiulcer effects and justify the traditional usage of this herb to treat peptic ulcers.

PMID:
21182918
DOI:
10.1016/j.jep.2010.12.019
[Indexed for MEDLINE]

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