Format

Send to

Choose Destination
Eur J Immunol. 2011 Jan;41(1):12-7. doi: 10.1002/eji.201041024.

Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla.

Author information

1
Division of Molecular Immunology, Institute for Enzyme Research, University of Tokushima, Tokushima, Japan. mitsuru@ier.tokushima-u.ac.jp

Abstract

The current prevailing view regarding the role of Aire in self-tolerance is that it is involved in the transcriptional control of many tissue-restricted self-antigen genes in thymic epithelial cells in the medulla (mTECs); however, accumulating evidence also suggests that Aire has other roles, e.g. in mTEC differentiation, and furthermore that Aire can either promote or inhibit the mTEC differentiation program, i.e. Aire does not play a neutral role in mTEC differentiation. This review discusses when and how Aire plays an important role in controlling the organization of mTECs required for the expression of self-antigen genes.

PMID:
21182071
DOI:
10.1002/eji.201041024
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center