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Int J Biol Sci. 2010 Dec 14;6(7):796-805.

Applications of patient-specific induced pluripotent stem cells; focused on disease modeling, drug screening and therapeutic potentials for liver disease.

Author information

1
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

Abstract

The recent advances in the induced pluripotent stem cell (iPSC) research have significantly changed our perspectives on regenerative medicine by providing researchers with a unique tool to derive disease-specific stem cells for study. In this review, we describe the human iPSC generation from developmentally diverse origins (i.e. endoderm-, mesoderm-, and ectoderm- tissue derived human iPSCs) and multistage hepatic differentiation protocols, and discuss both basic and clinical applications of these cells including disease modeling, drug toxicity screening/drug discovery, gene therapy and cell replacement therapy.

KEYWORDS:

Disease Modeling; Drug Screening; Liver Disease; Stem Cell

PMID:
21179587
PMCID:
PMC3005346
[Indexed for MEDLINE]
Free PMC Article
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