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Nat Rev Mol Cell Biol. 2011 Jan;12(1):14-20. doi: 10.1038/nrm3029.

Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation.

Author information

1
Abteilung für Biochemie II, Universität Göttingen, D-37073 Göttingen, Germany.

Abstract

Mitochondria maintain genome and translation machinery to synthesize a small subset of subunits of the oxidative phosphorylation system. To build up functional enzymes, these organellar gene products must assemble with imported subunits that are encoded in the nucleus. New findings on the early steps of cytochrome c oxidase assembly reveal how the mitochondrial translation of its core component, cytochrome c oxidase subunit 1 (Cox1), is directly coupled to the assembly of this respiratory complex.

PMID:
21179059
PMCID:
PMC3376542
DOI:
10.1038/nrm3029
[Indexed for MEDLINE]
Free PMC Article

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