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AIDS. 2011 Feb 20;25(4):525-9. doi: 10.1097/QAD.0b013e328342fdfd.

Vitamin D deficiency is associated with type 2 diabetes mellitus in HIV infection.

Author information

1
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, USA. zsofia.szep@uphs.upenn.edu

Erratum in

  • AIDS. 2011 Aug 24;25(13):1682.

Abstract

BACKGROUND:

Metabolic complications, including type 2 diabetes mellitus and metabolic syndrome, are increasingly recognized among HIV-infected individuals. Low vitamin D levels increase the risk of type 2 diabetes mellitus, and vitamin D supplementation has been shown to decrease the risk of type 2 diabetes mellitus in patients without HIV infection.

OBJECTIVES:

The primary objective was to determine whether vitamin D deficiency (serum 25-hyrdoxyvitamin D <20 ng/ml) was associated with type 2 diabetes mellitus among HIV-infected patients. Our secondary objective was to determine whether vitamin D deficiency was associated with metabolic syndrome in HIV.

METHODS:

We conducted a cross-sectional study among participants enrolled in the prospective Modena (Italy) HIV Metabolic Clinic Cohort. Clinical and laboratory data, including history of type 2 diabetes mellitus, fasting blood glucose, components of metabolic syndrome, and 25-hydroxyvitamin D levels, were obtained for all participants.

RESULTS:

After adjusting for vitamin D supplementation, sex, age, body mass index, and hepatitis C virus co-infection, vitamin D deficiency was associated with type 2 diabetes mellitus [adjusted odds ratio (OR) 1.85; 95% confidence interval (CI) 1.03-3.32; P = 0.038]. The association between vitamin D deficiency and metabolic syndrome was not significant after adjusting for vitamin D supplementation, sex, age and body mass index (adjusted OR 1.32; 95% CI 1.00-1.75; P = 0.053).

CONCLUSIONS:

Our study demonstrates an association between vitamin D deficiency and type 2 diabetes mellitus. Clinical trials are needed to better characterize the association between vitamin D deficiency and type 2 diabetes mellitus in HIV infection and to evaluate whether vitamin D is able to prevent or delay the onset of type 2 diabetes mellitus.

PMID:
21178753
PMCID:
PMC3366629
DOI:
10.1097/QAD.0b013e328342fdfd
[Indexed for MEDLINE]
Free PMC Article

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